Abstract: With 10 years'statistical data and the date of thunderstorm-day in 35 years of Lightning disaster in Guangdong province, lightning strike density, lightning disaster frequency, economic loss rate and population exposed to lightning disaster are selected as vulnerability evaluation indexes. Based on detailed valuation of district and county in Guangdong, a comprehensive evaluation of the weakness and vulnerability of lightning district and country in Guangdong is made and the vulnerability degree of lightning district is calculated. And also vulnerability zoning is made in Guangdong by means of GIS. Accordingly, a model for regional vulnerability analysis and evaluation of lightning disaster is developed, which provides scientific basis for the planning of regional lightning disaster prevention and reduction.