Abstract: Climate change has attracted great attention of the whole world.In this paper the spatio-temporal changes of climate,based on meteorological data in the Karst region of Chongqing,were analyzed by applying regression analysis and Kriging interpolation and a trend was forecasted of future climate by wavelet analysis.Results show the followings.(1) As a whole,the trend of annually averaged air temperature was declining in the past 40 years,especially the 1980's when the coldest period appeared.(2) The region getting warm appeared in the northeast of Chongqing while the region getting cold occurred in the middle and southeast of Chongqing.(3) The precipitation in the 40 years decreased slightly,mainly in spring and autumn.For each period and each region,the changes of precipitation and air temperature showed a reverse tendency.In the coldest 1980's,precipitation was the most.Precipitation decreases occur mainly in the north of Chongqing,where air temperature increased.(4) Over the next 8 years the trend of air temperature will be ascending while the trend of precipitation will be descending.Through discussing the climate change and making predictions of the climate trend,better understanding can be obtained of the interactions between climate change and ecosystem in Chongqing,and scientific base is provided for restoration and reconstruction of the Karst ecosystem.