Abstract: Using the Yin-Yang-grid Unified Model for the Atmosphere (YUNMA), we evaluated the impact of varying grid uniformity and horizontal resolutions on the simulation of vortices. Grids with different uniformity were obtained along the vortex paths through coordinated rotation. Combined with idealized vortex experiments and real typhoon case simulations, we analyzed the effects of grid uniformity and horizontal resolution on the simulated performances of the path, intensity, structure and precipitation of the vortex or typhoon. The key findings are as follows. (1) The grid uniformity clearly influences the purely dynamical numerical simulation results of the idealized vortex. Non-uniform grid tended to disturb the path of vortex and accelerate the decay of vortex intensity and moving speed. (2) Low-resolution simulation is more sensitive to the grid uniformity than the high-resolution simulation. The high-resolution dynamical model simulated more stable vortex intensity and paths than low-resolution models with the same grid-spacing variability, and the moving speed of the vortex was more easily maintained in numerical simulations. (3) Real typhoon simulations are also significantly affected by the grid uniformity. Uniform grid combined with high-resolution models can more accurately capture the path and intensity of typhoon. The low-resolution and non-uniform grid configurations model, however, simulated offset path of the typhoon, leading to significantly increased path simulation errors. Meanwhile, uniform-grid model demonstrated superior capability in reproducing precipitation with high Threat Score (TS). The non-uniform grids not only restrict the effectiveness of subgrid-scale physics parameterizations but also influence the spatial consistency of dynamical computational accuracy in numerical models, thereby affecting the overall simulation performance, including the movement, intensity, and precipitation of weather systems.